Chlorine in PDB 5ee7: Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893

All present enzymatic activity of Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893:
3.2.1.17;

The structure of Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893, PDB code: 5ee7 was solved by A.Jazayeri, A.S.Dore, D.Lamb, H.Krishnamurthy, S.M.Southall, A.H.Baig, A.Bortolato, M.Koglin, N.J.Robertson, J.C.Errey, S.P.Andrews, A.J.H.Brown, R.M.Cooke, M.Weir, F.H.Marshall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.97 / 2.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	37.583, 71.476, 183.108, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 26.3

The binding sites of Chlorine atom in the Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893 (pdb code 5ee7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893, PDB code: 5ee7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1201 b:64.0 occ:1.00 CL1 A:5MV1201 0.0 64.0 1.0 C3 A:5MV1201 1.7 49.5 1.0 C4 A:5MV1201 2.7 45.6 1.0 C2 A:5MV1201 2.7 45.6 1.0 C7 A:OLA1214 3.3 56.8 1.0 C5 A:OLA1214 3.4 56.0 1.0 C6 A:OLA1214 3.9 63.7 1.0 C5 A:5MV1201 4.0 52.1 1.0 C1 A:5MV1201 4.0 49.4 1.0 C8 A:OLA1214 4.5 51.7 1.0 C4 A:OLA1214 4.5 54.4 1.0 C6 A:5MV1201 4.5 49.4 1.0 C3 A:OLA1214 4.8 46.6 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Human Glucagon Receptor (Gcgr) in Complex with the Antagonist Mk-0893 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1201 b:54.8 occ:1.00 CL2 A:5MV1201 0.0 54.8 1.0 C5 A:5MV1201 1.7 52.1 1.0 C4 A:5MV1201 2.7 45.6 1.0 C6 A:5MV1201 2.7 49.4 1.0 C3 A:5MV1201 4.0 49.5 1.0 C1 A:5MV1201 4.0 49.4 1.0 C8 A:OLA1211 4.1 48.2 1.0 C2 A:5MV1201 4.5 45.6 1.0

A.Jazayeri, A.S.Dore, D.Lamb, H.Krishnamurthy, S.M.Southall, A.H.Baig, A.Bortolato, M.Koglin, N.J.Robertson, J.C.Errey, S.P.Andrews, I.Teobald, A.J.Brown, R.M.Cooke, M.Weir, F.H.Marshall. Extra-Helical Binding Site of A Glucagon Receptor Antagonist. Nature V. 533 274 2016.
ISSN: ESSN 1476-4687
PubMed: 27111510
DOI: 10.1038/NATURE17414