Chlorine in PDB 5hwx: Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+

The structure of Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+, PDB code: 5hwx was solved by J.Liao, Y.X.Jiang, J.D.Faraldo-Gomez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.92 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.702, 72.278, 95.783, 90.00, 90.00, 90.00
R / Rfree (%)	21 / 25.4

The structure of Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+ also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+ (pdb code 5hwx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+, PDB code: 5hwx:

Chlorine binding site 1 out of 1 in the Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Mechanisms of Extracellular Ion Exchange and Induced Binding-Site Occlusion in the Sodium-Calcium Exchanger NCX_MJ Soaked with 2.5 Mm Na+ and Zero CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:59.0 occ:1.00 N A:GLY227 3.3 44.8 1.0 ND2 A:ASN38 3.3 46.0 1.0 CA A:GLY227 3.8 40.0 1.0 N A:GLY226 3.8 47.4 1.0 C A:LEU225 3.8 46.3 1.0 CB A:ASN38 3.9 44.6 1.0 CA A:LEU225 3.9 43.5 1.0 CG A:ASN38 4.1 46.9 1.0 N A:MET228 4.2 43.7 1.0 C A:GLY226 4.3 45.8 1.0 O A:LEU225 4.4 45.4 1.0 CD2 A:LEU225 4.5 41.2 1.0 CB A:LEU225 4.5 41.9 1.0 C A:GLY227 4.5 45.5 1.0 CA A:GLY226 4.5 48.1 1.0 O A:ASN224 4.7 50.2 1.0

J.Liao, F.Marinelli, C.Lee, Y.Huang, J.D.Faraldo-Gomez, Y.Jiang. Mechanism of Extracellular Ion Exchange and Binding-Site Occlusion in A Sodium/Calcium Exchanger Nat.Struct.Mol.Biol. V. 23 590 2016.
ISSN: ESSN 1545-9985
PubMed: 27183196
DOI: 10.1038/NSMB.3230