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Chlorine in PDB 5iez: Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Protein crystallography data
The structure of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design, PDB code: 5iez
was solved by
B.Zhao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.84 / 2.60 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 39.914, 136.046, 63.499, 90.00, 101.62, 90.00 |
| R / Rfree (%) | 19.4 / 27.7 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
(pdb code 5iez). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design, PDB code: 5iez:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Chlorine where determined in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design, PDB code: 5iez:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Chlorine binding site 1 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 1 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 2 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 2 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 3 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 3 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 4 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 4 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 5 out of 8 in 5iez
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Chlorine Binding Sites List in 5iez
Chlorine binding site 5 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 6 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 6 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 7 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 7 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Chlorine binding site 8 out of 8 in 5iez
Go back to
Chlorine Binding Sites List in 5iez
Chlorine binding site 8 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design within 5.0Å range:
|
Reference:
T.Lee,
Z.Bian,
B.Zhao,
L.J.Hogdal,
J.L.Sensintaffar,
C.M.Goodwin,
J.Belmar,
S.Shaw,
J.C.Tarr,
N.Veerasamy,
S.M.Matulis,
B.Koss,
M.A.Fischer,
A.L.Arnold,
D.V.Camper,
C.F.Browning,
O.W.Rossanese,
A.Budhraja,
J.Opferman,
L.H.Boise,
M.R.Savona,
A.Letai,
E.T.Olejniczak,
S.W.Fesik.
Discovery and Biological Characterization of Potent Myeloid Cell Leukemia-1 Inhibitors. Febs Lett. V. 591 240 2017.
ISSN: ISSN 1873-3468
PubMed: 27878989
DOI: 10.1002/1873-3468.12497
Page generated: Fri Jul 26 09:16:26 2024
ISSN: ISSN 1873-3468
PubMed: 27878989
DOI: 10.1002/1873-3468.12497
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