Atomistry » Chlorine » PDB 5jsw-5jzn » 5jxq
Atomistry »
  Chlorine »
    PDB 5jsw-5jzn »
      5jxq »

Chlorine in PDB 5jxq: Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5jxq was solved by M.Neeb, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 69.93 / 1.20
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.220, 64.760, 70.340, 90.00, 96.16, 90.00
R / Rfree (%) 13.7 / 15.7

Other elements in 5jxq:

The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One (pdb code 5jxq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5jxq:

Chlorine binding site 1 out of 1 in 5jxq

Go back to Chlorine Binding Sites List in 5jxq
Chlorine binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trna-Guanine Transglycosylase (Tgt) in Complex with 6-Amino-2-{[4-(2- Hydroxyethyl)Phenethyl]Amino}-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl406

b:19.3
occ:1.00
 O A:HOH685 2.9 35.3 1.0
OG1 A:THR285 3.0 14.0 1.0
O A:HOH579 3.1 17.5 1.0
NH2 A:ARG289 3.3 17.0 1.0
O A:HOH751 3.5 38.9 1.0
CB A:THR285 3.6 13.4 1.0
O A:HOH759 3.7 39.8 1.0
N A:ARG286 3.7 14.1 1.0
NH1 A:ARG289 3.9 19.6 1.0
CB A:VAL282 3.9 18.6 1.0
CD A:LYS52 4.0 17.8 1.0
CB A:ARG286 4.0 17.8 1.0
CZ A:ARG289 4.1 17.9 1.0
CG1 A:VAL282 4.1 20.4 1.0
CA A:ARG286 4.1 15.7 1.0
O A:VAL282 4.1 16.0 1.0
CE A:LYS52 4.2 19.6 1.0
C A:THR285 4.3 14.0 1.0
CG A:LYS52 4.4 14.8 1.0
CA A:VAL282 4.5 15.1 1.0
CA A:THR285 4.5 13.7 1.0
CG2 A:THR285 4.7 15.1 1.0
CB A:LYS52 4.8 14.0 1.0
NE A:ARG286 4.8 29.2 1.0
C A:VAL282 4.8 14.6 1.0
O A:HOH634 5.0 14.5 1.0

Reference:

M.Neeb, C.Hohn, F.R.Ehrmann, A.Hartsch, A.Heine, F.Diederich, G.Klebe. Occupying A Flat Subpocket in A Trna-Modifying Enzyme with Ordered or Disordered Side Chains: Favorable or Unfavorable For Binding? Bioorg.Med.Chem. V. 24 4900 2016.
ISSN: ESSN 1464-3391
PubMed: 27501913
DOI: 10.1016/J.BMC.2016.07.053
Page generated: Fri Jul 26 10:18:10 2024

Last articles

Cl in 2XO2
Cl in 2XNO
Cl in 2XNM
Cl in 2XNG
Cl in 2XMN
Cl in 2XNE
Cl in 2XN5
Cl in 2XMS
Cl in 2XMG
Cl in 2XMD
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy