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Chlorine in PDB 5trf: MDM2 in Complex with SAR405838
Protein crystallography data
The structure of MDM2 in Complex with SAR405838, PDB code: 5trf
was solved by
J.L.Meagher,
J.A.Stuckey,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.09 / 2.10 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 138.849, 138.849, 83.707, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.5 / 20.8 |
Other elements in 5trf:
The structure of MDM2 in Complex with SAR405838 also contains other interesting chemical elements:
| Fluorine | (F) | 5 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the MDM2 in Complex with SAR405838
(pdb code 5trf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 10 binding sites of Chlorine where determined in the MDM2 in Complex with SAR405838, PDB code: 5trf:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
In total 10 binding sites of Chlorine where determined in the MDM2 in Complex with SAR405838, PDB code: 5trf:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
Chlorine binding site 1 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 1 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 2 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 2 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 3 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 3 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 4 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 4 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 5 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 5 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 6 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 6 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 7 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 7 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 8 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 8 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 9 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 9 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 9 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Chlorine binding site 10 out of 10 in 5trf
Go back to
Chlorine Binding Sites List in 5trf
Chlorine binding site 10 out
of 10 in the MDM2 in Complex with SAR405838
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 10 of MDM2 in Complex with SAR405838 within 5.0Å range:
|
Reference:
S.Wang,
W.Sun,
Y.Zhao,
D.Mceachern,
I.Meaux,
C.Barriere,
J.A.Stuckey,
J.L.Meagher,
L.Bai,
L.Liu,
C.G.Hoffman-Luca,
J.Lu,
S.Shangary,
S.Yu,
D.Bernard,
A.Aguilar,
O.Dos-Santos,
L.Besret,
S.Guerif,
P.Pannier,
D.Gorge-Bernat,
L.Debussche.
SAR405838: An Optimized Inhibitor of MDM2-P53 Interaction That Induces Complete and Durable Tumor Regression. Cancer Res. V. 74 5855 2014.
ISSN: ESSN 1538-7445
PubMed: 25145672
DOI: 10.1158/0008-5472.CAN-14-0799
Page generated: Fri Jul 26 17:39:59 2024
ISSN: ESSN 1538-7445
PubMed: 25145672
DOI: 10.1158/0008-5472.CAN-14-0799
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