Chlorine in PDB 5v6o: Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic

The structure of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic, PDB code: 5v6o was solved by G.Gonzalez-Gutierrez, C.Grosman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	70.44 / 3.12
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	178.388, 133.338, 160.312, 90.00, 101.77, 90.00
R / Rfree (%)	24 / 28

The structure of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Chlorine atom in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic (pdb code 5v6o). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic, PDB code: 5v6o:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl402 b:73.5 occ:1.00 N A:TYR221 3.6 64.7 1.0 CB A:TYR221 4.0 65.1 1.0 N A:ILE222 4.2 64.1 1.0 CA A:TYR221 4.3 62.6 1.0 CG2 A:ILE222 4.4 66.2 1.0 C A:SER220 4.4 65.7 1.0 OG A:SER220 4.5 63.3 1.0 CA A:SER220 4.5 57.7 1.0 C A:TYR221 4.8 63.1 1.0

Chlorine binding site 2 out of 5 in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl403 b:76.1 occ:1.00 N B:TYR221 3.4 71.2 1.0 CB B:TYR221 3.9 58.9 1.0 CA B:TYR221 4.2 61.9 1.0 N B:ILE222 4.2 63.7 1.0 CA B:SER220 4.2 65.7 1.0 C B:SER220 4.2 73.1 1.0 OG B:SER220 4.3 61.0 1.0 CG2 B:ILE222 4.7 61.8 1.0 C B:TYR221 4.7 66.2 1.0 O B:THR219 4.8 63.0 1.0 CB B:SER220 4.8 58.0 1.0

Chlorine binding site 3 out of 5 in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl403 b:75.4 occ:1.00 N D:TYR221 3.7 60.0 1.0 CB D:TYR221 3.8 55.8 1.0 CA D:TYR221 4.3 58.6 1.0 N D:ILE222 4.4 60.7 1.0 C D:SER220 4.5 63.3 1.0 CA D:SER220 4.6 68.2 1.0 C D:TYR221 4.9 62.4 1.0

Chlorine binding site 4 out of 5 in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl404 b:68.5 occ:1.00 N E:TYR221 3.4 66.3 1.0 CA E:SER220 3.7 60.8 1.0 CB E:SER220 3.9 51.9 1.0 C E:SER220 4.0 68.0 1.0 N E:ILE222 4.2 64.1 1.0 CB E:TYR221 4.3 58.5 1.0 CA E:TYR221 4.3 62.3 1.0 CG2 E:ILE222 4.5 66.5 1.0 O E:THR219 4.8 69.3 1.0 C E:TYR221 4.8 66.5 1.0

Chlorine binding site 5 out of 5 in the Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of the Highly Open Channel-Stabilized Mutant G-2'I + I9'A of Glic within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl404 b:76.8 occ:1.00 N C:TYR221 3.3 68.9 1.0 CA C:SER220 3.8 66.2 1.0 C C:SER220 3.9 63.6 1.0 CB C:SER220 4.0 56.6 1.0 N C:ILE222 4.0 65.6 1.0 CB C:TYR221 4.1 62.1 1.0 CA C:TYR221 4.2 64.9 1.0 CG2 C:ILE222 4.4 68.3 1.0 C C:TYR221 4.6 66.8 1.0 CB C:ILE222 4.9 65.7 1.0

G.Gonzalez-Gutierrez, Y.Wang, G.D.Cymes, E.Tajkhorshid, C.Grosman. Chasing the Open-State Structure of Pentameric Ligand-Gated Ion Channels. J. Gen. Physiol. V. 149 1119 2017.
ISSN: ESSN 1540-7748
PubMed: 29089419
DOI: 10.1085/JGP.201711803