Chlorine in PDB 6m12: Crystal Structure of Rnase L in Complex with SU11652

The structure of Crystal Structure of Rnase L in Complex with SU11652, PDB code: 6m12 was solved by J.Tang, H.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.30 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	58.710, 110.380, 262.590, 90.00, 90.00, 90.00
R / Rfree (%)	23.1 / 26.6

The binding sites of Chlorine atom in the Crystal Structure of Rnase L in Complex with SU11652 (pdb code 6m12). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Rnase L in Complex with SU11652, PDB code: 6m12:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Rnase L in Complex with SU11652


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Rnase L in Complex with SU11652 within 5.0Å range: probe atom residue distance (Å) B Occ a:Cl801 b:0.1 occ:1.00 CL a:J60801 0.0 0.1 1.0 CAA a:J60801 1.9 95.6 1.0 OD1 a:ASP500 2.4 88.0 1.0 CAB a:J60801 2.8 99.7 1.0 CAD a:J60801 2.9 81.4 1.0 CD1 a:LEU432 3.4 71.3 1.0 N a:ASP500 3.6 55.9 1.0 CG a:ASP500 3.6 81.2 1.0 CD a:LYS390 3.8 73.8 1.0 CB a:ALA499 3.8 51.3 1.0 CA a:ASP500 4.1 64.7 1.0 CAE a:J60801 4.1 86.5 1.0 CAC a:J60801 4.2 85.8 1.0 OE2 a:GLU402 4.3 79.9 1.0 NZ a:LYS390 4.3 74.4 1.0 CB a:ASP500 4.5 75.2 1.0 OD2 a:ASP500 4.5 89.5 1.0 C a:ALA499 4.5 51.2 1.0 CE a:LYS390 4.6 71.5 1.0 CAF a:J60801 4.6 83.7 1.0 CA a:ALA499 4.7 52.9 1.0 CD1 a:ILE377 4.7 70.7 1.0 CB a:LYS390 4.7 64.0 1.0 CG a:LEU432 4.8 65.4 1.0 CG a:LYS390 4.8 67.4 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Rnase L in Complex with SU11652


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Rnase L in Complex with SU11652 within 5.0Å range: probe atom residue distance (Å) B Occ b:Cl802 b:0.9 occ:1.00 CL b:J60802 0.0 0.9 1.0 CAA b:J60802 1.7 87.2 1.0 CAD b:J60802 2.6 78.5 1.0 CAB b:J60802 2.7 76.6 1.0 CD1 b:LEU432 3.3 53.5 1.0 CAE b:J60802 3.8 96.5 1.0 CAC b:J60802 3.9 81.7 1.0 CB b:ALA499 4.1 46.6 1.0 CD1 b:LEU489 4.2 53.7 1.0 OD1 b:ASP500 4.3 93.4 1.0 CAF b:J60802 4.3 91.3 1.0 CD1 b:ILE377 4.5 72.7 1.0 CG b:LEU432 4.6 52.6 1.0 CB b:LEU432 4.7 48.5 1.0 CD b:LYS390 5.0 67.9 1.0

J.Tang, Y.Wang, H.Zhou, Y.Ye, M.Talukdar, Z.Fu, Z.Liu, J.Li, D.Neculai, J.Gao, H.Huang. Sunitinib Inhibits Rnase L By Destabilizing Its Active Dimer Conformation. Biochem.J. V. 477 3387 2020.
ISSN: ESSN 1470-8728
PubMed: 32830849
DOI: 10.1042/BCJ20200260