Chlorine in PDB 6skh: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp, PDB code: 6skh was solved by L.Motlova, Z.Novakova, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.21 / 1.58
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.629, 130.530, 159.192, 90.00, 90.00, 90.00
R / Rfree (%) 17.1 / 19.3

Other elements in 6skh:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp (pdb code 6skh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp, PDB code: 6skh:

Chlorine binding site 1 out of 1 in 6skh

Go back to Chlorine Binding Sites List in 6skh
Chlorine binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl823

b:22.8
occ:1.00
 O A:HOH968 3.2 22.0 1.0
ND2 A:ASN451 3.2 19.4 1.0
N A:ASP453 3.3 19.1 1.0
NE A:ARG534 3.4 22.4 1.0
NH2 A:ARG534 3.4 22.1 1.0
NH2 A:ARG536 3.6 28.6 1.0
CB A:ASP453 3.7 19.2 1.0
CZ A:ARG534 3.9 22.4 1.0
CA A:ASP453 3.9 19.7 1.0
CB A:ARG534 3.9 19.2 1.0
NH2 A:ARG580 4.0 20.0 1.0
CG A:ASN451 4.1 19.3 1.0
CB A:ASN451 4.1 17.8 1.0
C A:ASP453 4.2 21.1 1.0
N A:ALA452 4.2 19.7 1.0
O A:ASP453 4.3 21.1 1.0
C A:ALA452 4.3 19.2 1.0
C A:ASN451 4.4 20.1 1.0
CZ A:ARG536 4.4 31.7 1.0
CA A:ALA452 4.4 19.5 1.0
NE A:ARG536 4.5 29.1 1.0
CD A:ARG534 4.5 21.6 1.0
O A:ASN451 4.5 21.8 1.0
O A:SER454 4.6 21.1 0.8
CG A:ARG534 4.6 20.4 1.0
O A:SER454 4.7 21.8 0.2
N A:SER454 4.8 19.8 0.8
CZ A:ARG580 4.8 20.3 1.0
N A:SER454 4.9 21.0 0.2
ND2 A:ASN519 4.9 18.7 1.0
O A:ALA535 4.9 20.5 1.0
CA A:ARG534 4.9 18.9 1.0
CA A:ASN451 5.0 18.1 1.0
N A:ALA535 5.0 20.4 1.0

Reference:

L.Motlova, Z.Novakova, C.Barinka. X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp To Be Published.
Page generated: Sat Dec 12 13:40:07 2020

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