Chlorine in PDB 6uz8: Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883
(pdb code 6uz8). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the
Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883, PDB code: 6uz8:
Jump to Chlorine binding site number:
1;
2;
3;
4;
Chlorine binding site 1 out
of 4 in 6uz8
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Chlorine Binding Sites List in 6uz8
Chlorine binding site 1 out
of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl1003
b:41.8
occ:1.00
|
CL01
|
A:R0D1003
|
0.0
|
41.8
|
1.0
|
C02
|
A:R0D1003
|
1.7
|
41.8
|
1.0
|
C03
|
A:R0D1003
|
2.7
|
41.8
|
1.0
|
C27
|
A:R0D1003
|
2.7
|
41.8
|
1.0
|
CD1
|
D:PHE675
|
3.6
|
40.1
|
1.0
|
CG1
|
D:VAL671
|
3.9
|
48.0
|
1.0
|
CG
|
D:PHE675
|
3.9
|
40.1
|
1.0
|
CB
|
D:PHE675
|
4.0
|
40.1
|
1.0
|
C04
|
A:R0D1003
|
4.0
|
41.8
|
1.0
|
C26
|
A:R0D1003
|
4.0
|
41.8
|
1.0
|
O
|
D:VAL671
|
4.2
|
48.0
|
1.0
|
CE1
|
D:PHE675
|
4.3
|
40.1
|
1.0
|
C05
|
A:R0D1003
|
4.4
|
41.8
|
1.0
|
C
|
D:VAL671
|
4.5
|
48.0
|
1.0
|
CA
|
D:GLU672
|
4.8
|
47.6
|
1.0
|
CD2
|
D:PHE675
|
4.8
|
40.1
|
1.0
|
SD
|
D:MET649
|
4.8
|
45.6
|
1.0
|
N
|
D:GLU672
|
4.8
|
47.6
|
1.0
|
CB
|
D:VAL671
|
4.9
|
48.0
|
1.0
|
|
Chlorine binding site 2 out
of 4 in 6uz8
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Chlorine Binding Sites List in 6uz8
Chlorine binding site 2 out
of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl1003
b:41.8
occ:1.00
|
CL01
|
D:R0D1003
|
0.0
|
41.8
|
1.0
|
C02
|
D:R0D1003
|
1.7
|
41.8
|
1.0
|
C03
|
D:R0D1003
|
2.7
|
41.8
|
1.0
|
C27
|
D:R0D1003
|
2.7
|
41.8
|
1.0
|
CD1
|
C:PHE675
|
3.6
|
40.1
|
1.0
|
CG1
|
C:VAL671
|
3.9
|
48.0
|
1.0
|
CG
|
C:PHE675
|
3.9
|
40.1
|
1.0
|
CB
|
C:PHE675
|
4.0
|
40.1
|
1.0
|
C04
|
D:R0D1003
|
4.0
|
41.8
|
1.0
|
C26
|
D:R0D1003
|
4.0
|
41.8
|
1.0
|
O
|
C:VAL671
|
4.2
|
48.0
|
1.0
|
CE1
|
C:PHE675
|
4.3
|
40.1
|
1.0
|
C05
|
D:R0D1003
|
4.4
|
41.8
|
1.0
|
C
|
C:VAL671
|
4.5
|
48.0
|
1.0
|
CA
|
C:GLU672
|
4.8
|
47.6
|
1.0
|
CD2
|
C:PHE675
|
4.8
|
40.1
|
1.0
|
SD
|
C:MET649
|
4.8
|
45.6
|
1.0
|
N
|
C:GLU672
|
4.8
|
47.6
|
1.0
|
CB
|
C:VAL671
|
4.9
|
48.0
|
1.0
|
|
Chlorine binding site 3 out
of 4 in 6uz8
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Chlorine Binding Sites List in 6uz8
Chlorine binding site 3 out
of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl1001
b:41.8
occ:1.00
|
CL01
|
B:R0D1001
|
0.0
|
41.8
|
1.0
|
C02
|
B:R0D1001
|
1.7
|
41.8
|
1.0
|
C03
|
B:R0D1001
|
2.7
|
41.8
|
1.0
|
C27
|
B:R0D1001
|
2.7
|
41.8
|
1.0
|
CD1
|
A:PHE675
|
3.6
|
40.1
|
1.0
|
CG1
|
A:VAL671
|
3.9
|
48.0
|
1.0
|
CG
|
A:PHE675
|
3.9
|
40.1
|
1.0
|
CB
|
A:PHE675
|
4.0
|
40.1
|
1.0
|
C04
|
B:R0D1001
|
4.0
|
41.8
|
1.0
|
C26
|
B:R0D1001
|
4.0
|
41.8
|
1.0
|
O
|
A:VAL671
|
4.2
|
48.0
|
1.0
|
CE1
|
A:PHE675
|
4.3
|
40.1
|
1.0
|
C05
|
B:R0D1001
|
4.4
|
41.8
|
1.0
|
C
|
A:VAL671
|
4.5
|
48.0
|
1.0
|
CA
|
A:GLU672
|
4.8
|
47.6
|
1.0
|
CD2
|
A:PHE675
|
4.8
|
40.1
|
1.0
|
SD
|
A:MET649
|
4.8
|
45.6
|
1.0
|
N
|
A:GLU672
|
4.8
|
47.6
|
1.0
|
CB
|
A:VAL671
|
4.9
|
48.0
|
1.0
|
|
Chlorine binding site 4 out
of 4 in 6uz8
Go back to
Chlorine Binding Sites List in 6uz8
Chlorine binding site 4 out
of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl1001
b:41.8
occ:1.00
|
CL01
|
C:R0D1001
|
0.0
|
41.8
|
1.0
|
C02
|
C:R0D1001
|
1.7
|
41.8
|
1.0
|
C03
|
C:R0D1001
|
2.7
|
41.8
|
1.0
|
C27
|
C:R0D1001
|
2.7
|
41.8
|
1.0
|
CD1
|
B:PHE675
|
3.6
|
40.1
|
1.0
|
CG1
|
B:VAL671
|
3.9
|
48.0
|
1.0
|
CG
|
B:PHE675
|
3.9
|
40.1
|
1.0
|
CB
|
B:PHE675
|
4.0
|
40.1
|
1.0
|
C04
|
C:R0D1001
|
4.0
|
41.8
|
1.0
|
C26
|
C:R0D1001
|
4.0
|
41.8
|
1.0
|
O
|
B:VAL671
|
4.2
|
48.0
|
1.0
|
CE1
|
B:PHE675
|
4.3
|
40.1
|
1.0
|
C05
|
C:R0D1001
|
4.4
|
41.8
|
1.0
|
C
|
B:VAL671
|
4.5
|
48.0
|
1.0
|
CA
|
B:GLU672
|
4.8
|
47.6
|
1.0
|
CD2
|
B:PHE675
|
4.8
|
40.1
|
1.0
|
SD
|
B:MET649
|
4.8
|
45.6
|
1.0
|
N
|
B:GLU672
|
4.8
|
47.6
|
1.0
|
CB
|
B:VAL671
|
4.9
|
48.0
|
1.0
|
|
Reference:
Y.Bai,
X.Yu,
H.Chen,
D.Horne,
R.White,
X.Wu,
P.Lee,
Y.Gu,
S.Ghimire-Rijal,
D.C.Lin,
X.Huang.
Structural Basis For Pharmacological Modulation of the TRPC6 Channel. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32149605
DOI: 10.7554/ELIFE.53311
Page generated: Mon Jul 29 16:03:01 2024
|