Chlorine in PDB 6uz8: Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883

The binding sites of Chlorine atom in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 (pdb code 6uz8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883, PDB code: 6uz8:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1003 b:41.8 occ:1.00 CL01 A:R0D1003 0.0 41.8 1.0 C02 A:R0D1003 1.7 41.8 1.0 C03 A:R0D1003 2.7 41.8 1.0 C27 A:R0D1003 2.7 41.8 1.0 CD1 D:PHE675 3.6 40.1 1.0 CG1 D:VAL671 3.9 48.0 1.0 CG D:PHE675 3.9 40.1 1.0 CB D:PHE675 4.0 40.1 1.0 C04 A:R0D1003 4.0 41.8 1.0 C26 A:R0D1003 4.0 41.8 1.0 O D:VAL671 4.2 48.0 1.0 CE1 D:PHE675 4.3 40.1 1.0 C05 A:R0D1003 4.4 41.8 1.0 C D:VAL671 4.5 48.0 1.0 CA D:GLU672 4.8 47.6 1.0 CD2 D:PHE675 4.8 40.1 1.0 SD D:MET649 4.8 45.6 1.0 N D:GLU672 4.8 47.6 1.0 CB D:VAL671 4.9 48.0 1.0

Chlorine binding site 2 out of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1003 b:41.8 occ:1.00 CL01 D:R0D1003 0.0 41.8 1.0 C02 D:R0D1003 1.7 41.8 1.0 C03 D:R0D1003 2.7 41.8 1.0 C27 D:R0D1003 2.7 41.8 1.0 CD1 C:PHE675 3.6 40.1 1.0 CG1 C:VAL671 3.9 48.0 1.0 CG C:PHE675 3.9 40.1 1.0 CB C:PHE675 4.0 40.1 1.0 C04 D:R0D1003 4.0 41.8 1.0 C26 D:R0D1003 4.0 41.8 1.0 O C:VAL671 4.2 48.0 1.0 CE1 C:PHE675 4.3 40.1 1.0 C05 D:R0D1003 4.4 41.8 1.0 C C:VAL671 4.5 48.0 1.0 CA C:GLU672 4.8 47.6 1.0 CD2 C:PHE675 4.8 40.1 1.0 SD C:MET649 4.8 45.6 1.0 N C:GLU672 4.8 47.6 1.0 CB C:VAL671 4.9 48.0 1.0

Chlorine binding site 3 out of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:41.8 occ:1.00 CL01 B:R0D1001 0.0 41.8 1.0 C02 B:R0D1001 1.7 41.8 1.0 C03 B:R0D1001 2.7 41.8 1.0 C27 B:R0D1001 2.7 41.8 1.0 CD1 A:PHE675 3.6 40.1 1.0 CG1 A:VAL671 3.9 48.0 1.0 CG A:PHE675 3.9 40.1 1.0 CB A:PHE675 4.0 40.1 1.0 C04 B:R0D1001 4.0 41.8 1.0 C26 B:R0D1001 4.0 41.8 1.0 O A:VAL671 4.2 48.0 1.0 CE1 A:PHE675 4.3 40.1 1.0 C05 B:R0D1001 4.4 41.8 1.0 C A:VAL671 4.5 48.0 1.0 CA A:GLU672 4.8 47.6 1.0 CD2 A:PHE675 4.8 40.1 1.0 SD A:MET649 4.8 45.6 1.0 N A:GLU672 4.8 47.6 1.0 CB A:VAL671 4.9 48.0 1.0

Chlorine binding site 4 out of 4 in the Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of Human TRPC6 in Complex with Agonist Am-0883 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1001 b:41.8 occ:1.00 CL01 C:R0D1001 0.0 41.8 1.0 C02 C:R0D1001 1.7 41.8 1.0 C03 C:R0D1001 2.7 41.8 1.0 C27 C:R0D1001 2.7 41.8 1.0 CD1 B:PHE675 3.6 40.1 1.0 CG1 B:VAL671 3.9 48.0 1.0 CG B:PHE675 3.9 40.1 1.0 CB B:PHE675 4.0 40.1 1.0 C04 C:R0D1001 4.0 41.8 1.0 C26 C:R0D1001 4.0 41.8 1.0 O B:VAL671 4.2 48.0 1.0 CE1 B:PHE675 4.3 40.1 1.0 C05 C:R0D1001 4.4 41.8 1.0 C B:VAL671 4.5 48.0 1.0 CA B:GLU672 4.8 47.6 1.0 CD2 B:PHE675 4.8 40.1 1.0 SD B:MET649 4.8 45.6 1.0 N B:GLU672 4.8 47.6 1.0 CB B:VAL671 4.9 48.0 1.0

Y.Bai, X.Yu, H.Chen, D.Horne, R.White, X.Wu, P.Lee, Y.Gu, S.Ghimire-Rijal, D.C.Lin, X.Huang. Structural Basis For Pharmacological Modulation of the TRPC6 Channel. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32149605
DOI: 10.7554/ELIFE.53311