Chlorine in PDB 7c44: Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A

The structure of Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A, PDB code: 7c44 was solved by X.Y.Cheng, B.L.Zhang, Z.K.Kuang, J.Yang, Z.C.Li, J.P.Yu, Z.T.Zhao, C.Z.Cao, Z.D.Su, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.61 / 1.65
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	47.470, 47.470, 91.190, 90.00, 90.00, 90.00
R / Rfree (%)	20.8 / 26.5

The binding sites of Chlorine atom in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A (pdb code 7c44). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A, PDB code: 7c44:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:31.2 occ:1.00 CL1 A:NUT201 0.0 31.2 1.0 C22 A:NUT201 1.7 29.8 1.0 C21 A:NUT201 2.7 32.7 1.0 C23 A:NUT201 2.7 31.6 1.0 H25 A:NUT201 2.8 32.7 1.0 H24 A:NUT201 2.8 31.6 1.0 HD21 A:LEU97 2.8 37.0 1.0 HB3 A:LEU55 2.9 28.5 1.0 HD12 A:ILE59 3.1 28.7 1.0 HD22 A:LEU97 3.1 37.0 1.0 HD11 A:ILE59 3.2 28.7 1.0 HZ A:PHE89 3.2 37.5 1.0 CD2 A:LEU97 3.4 37.0 1.0 HD13 A:LEU97 3.5 42.2 1.0 HD13 A:LEU55 3.5 30.6 1.0 CD1 A:ILE59 3.5 28.7 1.0 HD12 A:LEU97 3.7 42.2 1.0 CB A:LEU55 3.8 28.5 1.0 HD13 A:ILE59 3.9 28.7 1.0 C20 A:NUT201 3.9 31.4 1.0 HB2 A:LEU55 4.0 28.5 1.0 CD1 A:LEU97 4.0 42.2 1.0 C24 A:NUT201 4.0 33.1 1.0 CZ A:PHE89 4.1 37.5 1.0 HD23 A:LEU97 4.1 37.0 1.0 HD21 A:LEU55 4.3 30.2 1.0 CG A:LEU97 4.3 39.0 1.0 CD1 A:LEU55 4.3 30.6 1.0 HE1 A:PHE89 4.3 37.3 1.0 HD22 A:LEU80 4.4 31.3 1.0 C19 A:NUT201 4.5 31.1 1.0 HD11 A:LEU55 4.5 30.6 1.0 C A:LEU55 4.5 27.8 1.0 CG A:LEU55 4.6 30.5 1.0 CE1 A:PHE89 4.6 37.3 1.0 HE1 A:MET52 4.6 40.1 1.0 O A:LEU55 4.7 28.2 1.0 HA2 A:GLY56 4.7 29.2 1.0 HE3 A:MET52 4.7 40.1 1.0 H26 A:NUT201 4.7 31.4 1.0 H23 A:NUT201 4.7 33.1 1.0 HB2 A:LEU97 4.7 31.7 1.0 N A:GLY56 4.8 28.6 1.0 HG13 A:ILE59 4.8 26.5 1.0 CA A:LEU55 4.8 27.1 1.0 CG1 A:ILE59 4.8 26.5 1.0 HD12 A:LEU80 4.8 28.9 1.0 HD11 A:LEU97 4.9 42.2 1.0 CD2 A:LEU55 4.9 30.2 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:40.6 occ:1.00 CL A:NUT201 0.0 40.6 1.0 C15 A:NUT201 1.7 38.2 1.0 C14 A:NUT201 2.6 36.9 1.0 H32 A:NUT201 2.7 36.9 1.0 C16 A:NUT201 2.7 37.5 1.0 H31 A:NUT201 2.9 37.5 1.0 HD23 A:LEU97 3.0 37.0 1.0 HB2 A:PRO94 3.0 41.6 1.0 HE2 A:TYR98 3.2 38.8 1.0 HE2 A:MET52 3.5 40.1 1.0 HB3 A:PRO94 3.7 41.6 1.0 CB A:PRO94 3.7 41.6 1.0 CE2 A:TYR98 3.7 38.8 1.0 HG3 A:PRO94 3.8 40.2 1.0 CD2 A:LEU97 3.8 37.0 1.0 HE1 A:MET52 3.9 40.1 1.0 C13 A:NUT201 3.9 32.8 1.0 HD22 A:LEU97 4.0 37.0 1.0 C17 A:NUT201 4.0 37.6 1.0 HG A:LEU97 4.0 39.0 1.0 CG A:PRO94 4.1 40.2 1.0 CE A:MET52 4.1 40.1 1.0 HB3 A:LEU97 4.2 31.7 1.0 HG2 A:PRO94 4.2 40.2 1.0 HD2 A:TYR98 4.3 36.3 1.0 CD2 A:TYR98 4.3 36.3 1.0 CZ A:TYR98 4.3 39.8 1.0 CG A:LEU97 4.4 39.0 1.0 OH A:TYR98 4.5 44.9 1.0 C12 A:NUT201 4.5 33.9 1.0 HD21 A:LEU97 4.6 37.0 1.0 HE3 A:MET52 4.6 40.1 1.0 H33 A:NUT201 4.7 32.8 1.0 H30 A:NUT201 4.7 37.6 1.0 CB A:LEU97 4.8 31.7 1.0

X.Y.Cheng, B.L.Zhang, Z.K.Kuang, J.Yang, Z.C.Li, J.P.Yu, Z.T.Zhao, C.Z.Cao, Z.D.Su. Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A To Be Published.