Chlorine in PDB 7c44: Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A
Protein crystallography data
The structure of Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A, PDB code: 7c44
was solved by
X.Y.Cheng,
B.L.Zhang,
Z.K.Kuang,
J.Yang,
Z.C.Li,
J.P.Yu,
Z.T.Zhao,
C.Z.Cao,
Z.D.Su,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
25.61 /
1.65
|
Space group
|
P 43 21 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
47.470,
47.470,
91.190,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
20.8 /
26.5
|
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A
(pdb code 7c44). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the
Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A, PDB code: 7c44:
Jump to Chlorine binding site number:
1;
2;
Chlorine binding site 1 out
of 2 in 7c44
Go back to
Chlorine Binding Sites List in 7c44
Chlorine binding site 1 out
of 2 in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl201
b:31.2
occ:1.00
|
CL1
|
A:NUT201
|
0.0
|
31.2
|
1.0
|
C22
|
A:NUT201
|
1.7
|
29.8
|
1.0
|
C21
|
A:NUT201
|
2.7
|
32.7
|
1.0
|
C23
|
A:NUT201
|
2.7
|
31.6
|
1.0
|
H25
|
A:NUT201
|
2.8
|
32.7
|
1.0
|
H24
|
A:NUT201
|
2.8
|
31.6
|
1.0
|
HD21
|
A:LEU97
|
2.8
|
37.0
|
1.0
|
HB3
|
A:LEU55
|
2.9
|
28.5
|
1.0
|
HD12
|
A:ILE59
|
3.1
|
28.7
|
1.0
|
HD22
|
A:LEU97
|
3.1
|
37.0
|
1.0
|
HD11
|
A:ILE59
|
3.2
|
28.7
|
1.0
|
HZ
|
A:PHE89
|
3.2
|
37.5
|
1.0
|
CD2
|
A:LEU97
|
3.4
|
37.0
|
1.0
|
HD13
|
A:LEU97
|
3.5
|
42.2
|
1.0
|
HD13
|
A:LEU55
|
3.5
|
30.6
|
1.0
|
CD1
|
A:ILE59
|
3.5
|
28.7
|
1.0
|
HD12
|
A:LEU97
|
3.7
|
42.2
|
1.0
|
CB
|
A:LEU55
|
3.8
|
28.5
|
1.0
|
HD13
|
A:ILE59
|
3.9
|
28.7
|
1.0
|
C20
|
A:NUT201
|
3.9
|
31.4
|
1.0
|
HB2
|
A:LEU55
|
4.0
|
28.5
|
1.0
|
CD1
|
A:LEU97
|
4.0
|
42.2
|
1.0
|
C24
|
A:NUT201
|
4.0
|
33.1
|
1.0
|
CZ
|
A:PHE89
|
4.1
|
37.5
|
1.0
|
HD23
|
A:LEU97
|
4.1
|
37.0
|
1.0
|
HD21
|
A:LEU55
|
4.3
|
30.2
|
1.0
|
CG
|
A:LEU97
|
4.3
|
39.0
|
1.0
|
CD1
|
A:LEU55
|
4.3
|
30.6
|
1.0
|
HE1
|
A:PHE89
|
4.3
|
37.3
|
1.0
|
HD22
|
A:LEU80
|
4.4
|
31.3
|
1.0
|
C19
|
A:NUT201
|
4.5
|
31.1
|
1.0
|
HD11
|
A:LEU55
|
4.5
|
30.6
|
1.0
|
C
|
A:LEU55
|
4.5
|
27.8
|
1.0
|
CG
|
A:LEU55
|
4.6
|
30.5
|
1.0
|
CE1
|
A:PHE89
|
4.6
|
37.3
|
1.0
|
HE1
|
A:MET52
|
4.6
|
40.1
|
1.0
|
O
|
A:LEU55
|
4.7
|
28.2
|
1.0
|
HA2
|
A:GLY56
|
4.7
|
29.2
|
1.0
|
HE3
|
A:MET52
|
4.7
|
40.1
|
1.0
|
H26
|
A:NUT201
|
4.7
|
31.4
|
1.0
|
H23
|
A:NUT201
|
4.7
|
33.1
|
1.0
|
HB2
|
A:LEU97
|
4.7
|
31.7
|
1.0
|
N
|
A:GLY56
|
4.8
|
28.6
|
1.0
|
HG13
|
A:ILE59
|
4.8
|
26.5
|
1.0
|
CA
|
A:LEU55
|
4.8
|
27.1
|
1.0
|
CG1
|
A:ILE59
|
4.8
|
26.5
|
1.0
|
HD12
|
A:LEU80
|
4.8
|
28.9
|
1.0
|
HD11
|
A:LEU97
|
4.9
|
42.2
|
1.0
|
CD2
|
A:LEU55
|
4.9
|
30.2
|
1.0
|
|
Chlorine binding site 2 out
of 2 in 7c44
Go back to
Chlorine Binding Sites List in 7c44
Chlorine binding site 2 out
of 2 in the Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl201
b:40.6
occ:1.00
|
CL
|
A:NUT201
|
0.0
|
40.6
|
1.0
|
C15
|
A:NUT201
|
1.7
|
38.2
|
1.0
|
C14
|
A:NUT201
|
2.6
|
36.9
|
1.0
|
H32
|
A:NUT201
|
2.7
|
36.9
|
1.0
|
C16
|
A:NUT201
|
2.7
|
37.5
|
1.0
|
H31
|
A:NUT201
|
2.9
|
37.5
|
1.0
|
HD23
|
A:LEU97
|
3.0
|
37.0
|
1.0
|
HB2
|
A:PRO94
|
3.0
|
41.6
|
1.0
|
HE2
|
A:TYR98
|
3.2
|
38.8
|
1.0
|
HE2
|
A:MET52
|
3.5
|
40.1
|
1.0
|
HB3
|
A:PRO94
|
3.7
|
41.6
|
1.0
|
CB
|
A:PRO94
|
3.7
|
41.6
|
1.0
|
CE2
|
A:TYR98
|
3.7
|
38.8
|
1.0
|
HG3
|
A:PRO94
|
3.8
|
40.2
|
1.0
|
CD2
|
A:LEU97
|
3.8
|
37.0
|
1.0
|
HE1
|
A:MET52
|
3.9
|
40.1
|
1.0
|
C13
|
A:NUT201
|
3.9
|
32.8
|
1.0
|
HD22
|
A:LEU97
|
4.0
|
37.0
|
1.0
|
C17
|
A:NUT201
|
4.0
|
37.6
|
1.0
|
HG
|
A:LEU97
|
4.0
|
39.0
|
1.0
|
CG
|
A:PRO94
|
4.1
|
40.2
|
1.0
|
CE
|
A:MET52
|
4.1
|
40.1
|
1.0
|
HB3
|
A:LEU97
|
4.2
|
31.7
|
1.0
|
HG2
|
A:PRO94
|
4.2
|
40.2
|
1.0
|
HD2
|
A:TYR98
|
4.3
|
36.3
|
1.0
|
CD2
|
A:TYR98
|
4.3
|
36.3
|
1.0
|
CZ
|
A:TYR98
|
4.3
|
39.8
|
1.0
|
CG
|
A:LEU97
|
4.4
|
39.0
|
1.0
|
OH
|
A:TYR98
|
4.5
|
44.9
|
1.0
|
C12
|
A:NUT201
|
4.5
|
33.9
|
1.0
|
HD21
|
A:LEU97
|
4.6
|
37.0
|
1.0
|
HE3
|
A:MET52
|
4.6
|
40.1
|
1.0
|
H33
|
A:NUT201
|
4.7
|
32.8
|
1.0
|
H30
|
A:NUT201
|
4.7
|
37.6
|
1.0
|
CB
|
A:LEU97
|
4.8
|
31.7
|
1.0
|
|
Reference:
X.Y.Cheng,
B.L.Zhang,
Z.K.Kuang,
J.Yang,
Z.C.Li,
J.P.Yu,
Z.T.Zhao,
C.Z.Cao,
Z.D.Su.
Crystal Structure of the P53-Binding Domain of Human Mdmx Protein in Complex with NUTLIN3A To Be Published.
Page generated: Sun Dec 13 10:24:58 2020
|