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Atomistry » Chlorine » PDB 7kce-7km6 » 7kdb | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7kce-7km6 » 7kdb » |
Chlorine in PDB 7kdb: Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35Enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35
All present enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35:
2.5.1.6; Protein crystallography data
The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35, PDB code: 7kdb
was solved by
A.Padyana,
L.Jin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35
(pdb code 7kdb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35, PDB code: 7kdb: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7kdbGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 7kdbGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 35
![]() Mono view ![]() Stereo pair view
Reference:
Z.Konteatis,
J.Travins,
S.Gross,
K.Marjon,
A.Barnett,
E.Mandley,
B.Nicolay,
R.Nagaraja,
Y.Chen,
Y.Sun,
Z.Liu,
J.Yu,
Z.Ye,
F.Jiang,
W.Wei,
C.Fang,
Y.Gao,
P.Kalev,
M.L.Hyer,
B.Delabarre,
L.Jin,
A.K.Padyana,
L.Dang,
J.Murtie,
S.A.Biller,
Z.Sui,
K.M.Marks.
Discovery of Ag-270, A First-in-Class Oral MAT2A Inhibitor For the Treatment of Tumors with Homozygous Mtap Deletion. J.Med.Chem. 2021.
Page generated: Mon Jul 29 23:30:50 2024
ISSN: ISSN 0022-2623 PubMed: 33829783 DOI: 10.1021/ACS.JMEDCHEM.0C01895 |
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