Chlorine in PDB 8fup: Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477

All present enzymatic activity of Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477:
2.3.1.48;

The structure of Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477, PDB code: 8fup was solved by E.Schonbrunn, M.Bikowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.11 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.95, 53.46, 110.31, 90, 90, 90
R / Rfree (%)	18.6 / 21.3

The structure of Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477 also contains other interesting chemical elements:

Fluorine

(F)

4 atoms

The binding sites of Chlorine atom in the Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477 (pdb code 8fup). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477, PDB code: 8fup:

Chlorine binding site 1 out of 1 in the Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Bromodomain of Cbp Liganded with Bms-536924 and Ccs-1477 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1201 b:14.4 occ:1.00 CL16 A:N6I1201 0.0 14.4 1.0 C15 A:N6I1201 1.8 11.5 1.0 C14 A:N6I1201 2.7 11.9 1.0 C17 A:N6I1201 2.7 11.2 1.0 O A:HOH1320 3.6 26.8 1.0 CH2 A:TRP1151 3.7 11.7 1.0 CG A:MET1193 3.8 11.1 1.0 CA A:ASP1190 3.9 13.9 1.0 CB A:MET1193 4.0 11.6 1.0 CZ3 A:TRP1151 4.0 11.4 1.0 C13 A:N6I1201 4.0 12.0 1.0 C11 A:N6I1201 4.0 11.3 1.0 CG2 A:ILE1189 4.2 11.7 1.0 O A:ILE1189 4.3 11.2 1.0 N A:ASP1190 4.3 11.3 1.0 C A:ILE1189 4.5 12.0 1.0 C12 A:N6I1201 4.5 12.1 1.0 CB A:ASP1190 4.6 15.3 1.0 OD1 A:ASP1190 4.7 23.4 1.0 O A:ASP1190 4.7 13.3 1.0 CG A:ASP1190 4.7 22.6 1.0 CG1 A:ILE1189 4.8 10.8 1.0 CZ2 A:TRP1151 4.8 11.9 1.0 C A:ASP1190 4.9 12.8 1.0

E.Schonbrunn, M.Bikowitz. Structural Basis of Cbp and EP300 Interaction with Kinase Inhibitors To Be Published.