Chlorine in PDB 8d59: Crystal Structure of Human METTL1 in Complex with Sam

All present enzymatic activity of Crystal Structure of Human METTL1 in Complex with Sam:
2.1.1.33;

The structure of Crystal Structure of Human METTL1 in Complex with Sam, PDB code: 8d59 was solved by R.Raj, K.Babu, Y.Nam, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.25 / 2.26
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	86.026, 86.026, 65.579, 90, 90, 120
R / Rfree (%)	20.7 / 23

The structure of Crystal Structure of Human METTL1 in Complex with Sam also contains other interesting chemical elements:

Arsenic

(As)

1 atom

The binding sites of Chlorine atom in the Crystal Structure of Human METTL1 in Complex with Sam (pdb code 8d59). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human METTL1 in Complex with Sam, PDB code: 8d59:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human METTL1 in Complex with Sam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human METTL1 in Complex with Sam within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl305 b:46.9 occ:1.00 N A:GLY89 3.0 39.1 1.0 N A:GLU239 3.3 47.5 1.0 CA A:GLY89 3.5 37.6 1.0 N A:GLY88 3.6 44.1 1.0 C A:TYR87 3.6 43.4 1.0 CB A:TYR87 3.6 45.4 1.0 CA A:THR238 3.6 46.8 1.0 N A:TYR87 3.8 43.9 1.0 CA A:TYR87 3.8 42.5 1.0 CB A:THR238 3.9 43.5 1.0 C A:THR238 3.9 49.2 1.0 CG A:GLU239 4.0 64.8 1.0 C A:GLY88 4.1 41.5 1.0 O A:TYR87 4.1 37.2 1.0 CB A:GLU239 4.1 56.0 1.0 CA A:GLU239 4.3 49.3 1.0 CA A:GLY88 4.4 42.5 1.0 CG2 A:THR238 4.4 41.3 1.0 OXT A:SAM301 4.5 48.8 1.0 O A:SER237 4.6 47.2 1.0 O A:CYS85 4.6 44.6 1.0 C A:GLY89 4.8 44.1 1.0 CG A:TYR87 4.8 48.5 1.0 N A:THR238 4.9 36.2 1.0 C A:GLY86 4.9 48.9 1.0 O A:HOH422 4.9 38.2 1.0 CD2 A:TYR87 5.0 49.3 1.0

V.M.Ruiz-Arroyo, R.Raj, K.Babu, O.Onolbaatar, P.H.Roberts, Y.Nam. Structures and Mechanisms of Trna Methylation By METTL1-WDR4. Nature 2023.
ISSN: ESSN 1476-4687
PubMed: 36599982
DOI: 10.1038/S41586-022-05565-5