Chlorine in PDB 3tlv: The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype)

The structure of The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype), PDB code: 3tlv was solved by L.Sauguet, H.Nury, P.J.Corringer, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.23 / 2.90
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	179.140, 127.756, 160.866, 90.00, 101.55, 90.00
R / Rfree (%)	21.5 / 22.9

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype) (pdb code 3tlv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype), PDB code: 3tlv:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl319 b:61.5 occ:1.00 N A:PHE78 3.4 58.5 1.0 NH1 A:ARG85 3.4 43.1 1.0 N A:ARG85 3.4 62.8 1.0 CG A:ARG85 3.8 64.1 1.0 CA A:ALA84 3.8 63.9 1.0 CD2 A:PHE78 3.9 67.7 1.0 CB A:PHE78 3.9 60.8 1.0 CA A:ARG77 4.0 58.0 1.0 C A:ARG77 4.1 61.9 1.0 CG2 A:VAL81 4.1 66.6 1.0 C A:ALA84 4.1 68.1 1.0 CG A:PHE78 4.1 63.9 1.0 CB A:ARG85 4.1 61.2 1.0 CB A:ALA84 4.2 64.8 1.0 CA A:PHE78 4.2 58.1 1.0 CD A:ARG85 4.2 67.5 1.0 CB A:ARG77 4.4 54.7 1.0 CA A:ARG85 4.4 62.5 1.0 O A:PHE78 4.4 56.9 1.0 CZ A:ARG85 4.5 67.0 1.0 CE2 A:PHE78 4.8 72.1 1.0 NE A:ARG85 4.8 69.2 1.0 C A:PHE78 4.8 59.4 1.0 CG A:ARG77 4.9 53.0 1.0

Chlorine binding site 2 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl318 b:62.7 occ:1.00 NH1 B:ARG85 3.2 50.4 1.0 N B:PHE78 3.4 55.4 1.0 N B:ARG85 3.4 70.3 1.0 CG B:ARG85 3.7 59.8 1.0 CD2 B:PHE78 3.7 62.2 1.0 CA B:ALA84 3.8 71.6 1.0 CB B:PHE78 3.9 56.5 1.0 CA B:ARG77 4.0 55.3 1.0 CG B:PHE78 4.0 58.7 1.0 CB B:ARG85 4.0 64.0 1.0 CD B:ARG85 4.1 62.0 1.0 C B:ARG77 4.1 58.6 1.0 C B:ALA84 4.1 76.2 1.0 CB B:ALA84 4.1 72.1 1.0 CA B:PHE78 4.2 54.4 1.0 CG2 B:VAL81 4.2 63.6 1.0 CZ B:ARG85 4.3 64.4 1.0 CA B:ARG85 4.3 68.4 1.0 CB B:ARG77 4.5 50.3 1.0 O B:PHE78 4.6 57.4 1.0 CE2 B:PHE78 4.6 64.5 1.0 NE B:ARG85 4.6 49.1 1.0 O B:ILE76 4.9 64.9 1.0 C B:PHE78 4.9 57.2 1.0 CD1 B:PHE78 5.0 62.1 1.0

Chlorine binding site 3 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl318 b:58.5 occ:1.00 N C:PHE78 3.4 52.3 1.0 N C:ARG85 3.4 59.3 1.0 NH1 C:ARG85 3.4 59.2 1.0 CA C:ALA84 3.7 58.9 1.0 CG C:ARG85 3.8 59.9 1.0 CD2 C:PHE78 3.9 65.5 1.0 CA C:ARG77 4.0 51.2 1.0 CB C:PHE78 4.0 56.8 1.0 C C:ALA84 4.1 62.4 1.0 CG2 C:VAL81 4.1 64.9 1.0 C C:ARG77 4.1 53.9 1.0 CB C:ALA84 4.1 59.0 1.0 CB C:ARG85 4.2 55.8 1.0 CG C:PHE78 4.2 60.5 1.0 CA C:PHE78 4.2 53.8 1.0 CD C:ARG85 4.3 65.5 1.0 CB C:ARG77 4.3 48.4 1.0 O C:PHE78 4.4 62.8 1.0 CA C:ARG85 4.4 58.4 1.0 CZ C:ARG85 4.5 67.2 1.0 CE2 C:PHE78 4.8 69.4 1.0 C C:PHE78 4.8 61.1 1.0 NE C:ARG85 4.8 55.1 1.0 N C:ALA84 4.9 60.3 1.0 CG C:ARG77 4.9 52.8 1.0

Chlorine binding site 4 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl318 b:64.1 occ:1.00 NH1 D:ARG85 3.3 47.8 1.0 N D:ARG85 3.4 64.4 1.0 N D:PHE78 3.5 59.0 1.0 CG D:ARG85 3.7 60.9 1.0 CA D:ALA84 3.7 67.9 1.0 CD2 D:PHE78 3.9 66.1 1.0 CB D:PHE78 4.0 60.2 1.0 CB D:ALA84 4.0 68.1 1.0 CB D:ARG85 4.1 61.3 1.0 CA D:ARG77 4.1 56.8 1.0 C D:ALA84 4.1 71.6 1.0 CD D:ARG85 4.1 63.5 1.0 CG D:PHE78 4.2 62.5 1.0 CG2 D:VAL81 4.2 70.0 1.0 C D:ARG77 4.2 62.5 1.0 CA D:PHE78 4.3 58.5 1.0 CA D:ARG85 4.3 62.9 1.0 CZ D:ARG85 4.4 60.5 1.0 CB D:ARG77 4.5 53.0 1.0 O D:PHE78 4.6 61.8 1.0 NE D:ARG85 4.7 58.2 1.0 CE2 D:PHE78 4.7 68.9 1.0 N D:ALA84 5.0 69.6 1.0 C D:PHE78 5.0 62.7 1.0

Chlorine binding site 5 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel LOOP2-22' Oxidized Mutant in A Locally-Closed Conformation (LC3 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl318 b:64.7 occ:1.00 O E:HOH323 2.9 52.5 1.0 NH1 E:ARG85 3.1 47.7 1.0 N E:ARG85 3.3 60.0 1.0 N E:PHE78 3.5 55.5 1.0 CG E:ARG85 3.5 57.1 1.0 CD2 E:PHE78 3.7 65.4 1.0 CA E:ALA84 3.8 61.9 1.0 CB E:ARG85 3.9 59.8 1.0 CD E:ARG85 3.9 49.3 1.0 CA E:ARG77 4.0 52.4 1.0 CB E:PHE78 4.0 57.7 1.0 C E:ALA84 4.1 66.1 1.0 CG E:PHE78 4.1 60.9 1.0 CZ E:ARG85 4.2 57.6 1.0 C E:ARG77 4.2 57.3 1.0 CB E:ALA84 4.2 62.7 1.0 CA E:ARG85 4.2 59.8 1.0 CG2 E:VAL81 4.3 64.0 1.0 CA E:PHE78 4.4 55.5 1.0 NE E:ARG85 4.5 38.5 1.0 CE2 E:PHE78 4.5 68.6 1.0 CB E:ARG77 4.5 49.9 1.0 O E:PHE78 4.7 61.5 1.0 O E:ILE76 4.8 60.3 1.0

M.S.Prevost, L.Sauguet, H.Nury, C.Van Renterghem, C.Huon, F.Poitevin, M.Baaden, M.Delarue, P.J.Corringer. A Locally Closed Conformation of A Bacterial Pentameric Proton-Gated Ion Channel. Nat.Struct.Mol.Biol. V. 19 642 2012.
ISSN: ISSN 1545-9993
PubMed: 22580559
DOI: 10.1038/NSMB.2307