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Chlorine in PDB 6mju: Human Cgas Catalytic Domain Bound with the Inhibitor G108Enzymatic activity of Human Cgas Catalytic Domain Bound with the Inhibitor G108
All present enzymatic activity of Human Cgas Catalytic Domain Bound with the Inhibitor G108:
2.7.7.86; Protein crystallography data
The structure of Human Cgas Catalytic Domain Bound with the Inhibitor G108, PDB code: 6mju
was solved by
L.Lama,
C.Adura,
W.Xie,
D.Tomita,
T.Kamei,
V.Kuryavyi,
T.Gogakos,
J.I.Steinberg,
M.Miller,
L.Ramos-Espiritu,
Y.Asano,
S.Hashizume,
J.Aida,
T.Imaeda,
R.Okamoto,
A.J.Jennings,
M.Michinom,
T.Kuroita,
A.Stamford,
P.Gao,
P.Meinke,
J.F.Glickman,
D.J.Patel,
T.Tuschl,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6mju:
The structure of Human Cgas Catalytic Domain Bound with the Inhibitor G108 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human Cgas Catalytic Domain Bound with the Inhibitor G108
(pdb code 6mju). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Cgas Catalytic Domain Bound with the Inhibitor G108, PDB code: 6mju: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6mjuGo back to Chlorine Binding Sites List in 6mju
Chlorine binding site 1 out
of 2 in the Human Cgas Catalytic Domain Bound with the Inhibitor G108
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6mjuGo back to Chlorine Binding Sites List in 6mju
Chlorine binding site 2 out
of 2 in the Human Cgas Catalytic Domain Bound with the Inhibitor G108
Mono view Stereo pair view
Reference:
L.Lama,
C.Adura,
W.Xie,
D.Tomita,
T.Kamei,
V.Kuryavyi,
T.Gogakos,
J.I.Steinberg,
M.Miller,
L.Ramos-Espiritu,
Y.Asano,
S.Hashizume,
J.Aida,
T.Imaeda,
R.Okamoto,
A.J.Jennings,
M.Michino,
T.Kuroita,
A.Stamford,
P.Gao,
P.Meinke,
J.F.Glickman,
D.J.Patel,
T.Tuschl.
Development of Human Cgas-Specific Small-Molecule Inhibitors For Repression of Dsdna-Triggered Interferon Expression. Nat Commun V. 10 2261 2019.
Page generated: Sat Dec 12 13:21:29 2020
ISSN: ESSN 2041-1723 PubMed: 31113940 DOI: 10.1038/S41467-019-08620-4 |
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